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And if were asked to give one word to describe the Blood Sport communitys current state of affairs, I would suggest that word is divided. The Blood Sport community is no longer generically lumped into descriptive categories like Hunters or Trappers or Anglers. Today this community is separated into numerous sub sets that are identified with specific fish or wildlife species or hunting and fishing techniques. By any logical application of the word, the Blood Sports at the end of the first decade of the twenty first century are diverse. Read moreThose of us who hunt and fish are a strange lot, as diverse as any group can be and still be considered, as I and a few other introspective outdoor writers have suggested, members of one the Blood Sports community. Depending upon who is providing the description, we are both an economic engine and this nations first and only true conservationists. Given the dichotomous ground between these accurately descriptive labels, it is fair to ask, Are the Blood Sports really a homogenous community as the economists label us or, as we speed down the inexorable trail of modernity, have we finally reached a point where we will split into incompatible, competing factions? Read more I know the popular thing to do when youre regaling people with a story about fly fishing is to drop as many who you know names as possible so that you can get a few buffo points for the quality of the people youve met. I know this must be true because Ive got a whole collection of catchy named books by a guy whose publisher must pay extra for every big name he works into his stories. Ive only ever met briefly talked to might be more accurate one of these who you knows and from that limited exposure I didnt think he was all hed been cracked up to be. Actually, l didnt know how famous he was at the time. It happened on a pleasant fall evening and, well, it will soon be apparent why I wont be getting any of those extra points I just mentioned.
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For example, a trial design assuming an ACM rate of 15% and a 10% NI margin requires 402 patients for the primary analysis. However, an ACM rate of 10% would most likely require a narrower 7% NI margin to avoid the possibility of an excessive loss of a clinically relevant treatment effect, thereby resulting in an increase in required enrollment to approximately 550 patients. Therefore, a clinically relevant endpoint having an occurrence rate of 15%20%, which would allow use of a 10% NI margin, would enable the study to have sensitivity to rule out clinically meaningful differences, with a decreased sample size. 3. Differences in ACM among the nonventilated HABP nv HABP, ventilated HABP v HABP, and VABP groups suggest that pooling their outcomes raises methodological issues. Because a clinically meaningful endpoint of symptom improvement plus survival for nv HABP is supported by the historical data for community acquired bacterial pneumonia CABP , nv HABP could be studied separately utilizing a patient reported outcome PRO instrument, thereby standardizing symptom collection . Given these considerations, sponsors of recent studies generously provided access to HABP/VABP datasets for further statistically rigorous evaluation. We summarize our findings and recommendations, based on our prior submission to the FDA docket in 2017 . A 2 part statistical analysis plan specified: part 1, a descriptive analysis of 3 recent HABP/VABP studies to understand potential endpoints and analysis populations; and part 2, a definitive analysis of the 5 datasets that allowed the most detailed analyses . The FDA generously shared hypothesis generating analyses . Datasets are identified in the references .
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Each issue has a feature article which engages with the theme in some detail, followed by several shorter articles. A major problem with Internet publications is that of usage and citation of online sources. Without pagination, long articles are awkward to read and individual quotes and references difficult to locate. In terms of length, M/C articles are deliberately shorter than articles in printed academic journals, functioning as interventions into media and culture. In terms of reference, individual paragraphs are numbered as "bits", so that instead of guesses like "about three screens from the end" or a mere "no pagination given", when you cite M/C articles you can refer directly to the bit you're interested in. Additionally, at the end of each piece they provide a reference citation of the article line in MLA and APA styles, which you can copy and paste into your own list of references. There are still no universally accepted ways of citing Internet sources, but they hope this will help. This will be added to Academic Resources 2004 05 Internet MiniGuide. MedlinePlusedlinePlus is a goldmine of good health information from the world's largest medical library, the National Library of Medicine. Health professionals and consumers alike can depend on it for information that is authoritative and up to date. MedlinePlus has extensive information from the National Institutes of Health and other trusted sources on over 650 diseases and conditions.